[ABSTRACT] Somatoform disorders are a prevalent pathology in the general population and in the health system. In fact, they explain 10% of total health costs in developed countries and produces an important loss of quality of life. However, the research on the pharmacological treatment of these group of disorders is scarce. Maybe the main limitation has been the lack of psychiatric clasifications until recent years. In this paper, we review the main data on the subject, analyzing the use of anti