[ABSTRACT] Introduction: Quality of life shows psychological, social and biological state of patients with any disease; and positive and negative phenomena that it produces after therapy. To describe associated factors of quality of life in patients with breast cancer. Methods: We studied patients with clinical and histological diagnostic of Breast cancer in the Hospital Nacional Sur Este ? Cusco, from 1986 to 1999. We evaluated associated factors of quality of life, and we applied the Functiona