[ABSTRACT] The 102-T/C polymorphism of the 5-HT2A receptor gene was analysed in 159 patients with major depression and 164 unrelated and healthy controls using a case-control design. Allele and genotype frequencies did not differ between cases and controls. Nor were differences found according to sex, age of onset, melancholia, suicidal behaviour or family history of psychiatric illness. However, genotype distributions significantly differed between patients with seasonal pattern in their episod