Background. Little is known about the prognostic value of some neuropsychiatry manifestation (npm) in hiv-patients with crytococcal meningitis (cm).Objectives: to determine the prognostic value of some npm associated with cm and other neurological complications.Patients and method: a retrospective analysis of 142 patients fulfilling the diagnostic criteria for cm and severe immune suppression (cd4<100 cell/mm3) was done. We identified clinical manifestations of depression, delirium, mania, anxiety, psychosis and dementia.Results: the commonest npm on this series was delirium (47%) and manic episodes (33 %) followed by depression and anxiety (19 and 16 %). Dementia was not identified on this group.Conclusions: serial lumbar punctures contributed to improve npm such as: delirium and mania however similar patients with an associated decrease level of consciousness (stupor/coma) for more than 48 hours or associated hydrocephalus had fatal prognosis (p<0. 001)