Background. Little is known about the prognostic value of some neuropsychiatry manifestation (npm) in hiv-patients with crytococcal meningitis (cm).Objectives: to determine the prognostic value of some npm associated with cm and other neurological complications.Patients and method: a retrospective analysis of 142 patients fulfilling the diagnostic criteria for cm and severe immune suppression (cd4<100 cell/mm3) was done. We identified clinical manifestations of depression, delirium, mania